Department of Agriculture, Nutrition and Veterinary Sciences
University of Nevada/Mail Stop 202
1664 North Virginia Street
Reno, Nevada 89557
Office: (775) 784-7737
View Larger Map Building: Max Fleischmann Agriculture, Office 103
B.S. Biology, 1964, New York University
M.S. Biology, 1966, New York University
Ph.D. Experimental Hematology, 1969, New York University
AWARDS, HONORS, & PROFESSIONAL RECOGNITION
- 1979 – Research Career Scientist (Department of Veterans Affairs)
- 1997 – M.E.R.I.T. Award, NHLBI, NIH
- 1998-’02 Member, NIH Hematology I Study Section
- 1998- Associate Editor, Experimental Hematology
- 2000 – Associate Editor, Journal of Hematology and Stem Cell Research
- 2001 – President, Internal Society for Experimental Hematology
Almeida-Porada, M. G., Zanjani, E. D., Porada, C. D. 2010, Bone Marrow Stem Cells and Liver Regeneration., Experimental Hematoloy / Elsevier, 38(7), 574-580.
Porada, C. D., Sanada, C., Long, C. R., Wood, J. A., Desai, J., Frederick, N., Millsap, L., Bormann, C., Menges, S. L., Hann, C., Flores-Foxworth, G., Shin, T., Westhusin, M. E., Liu, W., Glimp, H., Zanjani, E. D., Lozier, J. N., Pliska, V., Stranzinger, G., Joerg, H., Kraemer, D. C., Almeida-Porada, M. G. 2010, Clinical and molecular characterization of a re-established line of sheep exhibiting hemophilia A., Journal of Thrombosis and Haemostasis, 8(2), 276-285.
Colletti, E. J., Airey, J. A., Liu, W., Simmons, P. J., Zanjani, E. D., Porada, C. D., Almeida-Porada, M. G. 2009, Generation of tissue-specific cells from MSC does not require fusion or donor-to-host mitochondrial/membrane transfer., Stem Cell Research, 2(2), 125-138.
Human mesenchymal stem cells (MSC) hold great promise for cellular replacement therapies. Despite their contributing to phenotypically distinct cells in multiple tissues, controversy remains regarding whether the phenotype switch results from a true differentiation process. Here, we studied the events occurring during the first 120 h after human MSC transplantation into a large animal model. We demonstrate that MSC, shortly after engrafting different tissues, undergo proliferation and rapidly initiate the differentiative process, changing their phenotype into tissue-specific cells. Thus, the final level of tissue-specific cell contribution is not determined solely by the initial level of engraftment of the MSC within that organ, but rather by the proliferative capability of the ensuing tissue-specific cells into which the MSC rapidly differentiate. Furthermore, we show that true differentiation, and not cell fusion or transfer of mitochondria or membrane-derived vesicles between transplanted and resident cells, is the primary mechanism contributing to the change of phenotype of MSC upon transplantation.
- Book or Chapter(s) in Books
Flake, A. W., Zanjani, E. D. 2009, In Utero Transplantation, F.R. Applebaum, S.J. Forman, R.S. Negrin, and K.G. Blume (Ed.), Thomas’ Hematopoietic Cell Transplantation, 4th Edition (pp. Chapter 40; pages 577-589). West Sussex: Wiley-Blackwell Publishing.